The European Union is at a crossroads that entails the adoption of historical decisions related to the existence of the European project. The UK’s exit from the EU became imminent even if it may imply costs both for those from the EU and those from the proximity. The attempts by the anti-European populist forces and by Russia to make use of any symptom revealing the disintegration of the EU and to multiply these are also imminent. That’s why the celebration of 60 year of the signing of the Rome Treaty (of March 25, 1957) represents the best opportunity for pragmatically pondering over the EU’s future.